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KMID : 1147520090020020128
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Korean Academy of Basic Medicine & Health Science
2009 Volume.2 No. 2 p.128 ~ p.131
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Effect of Taraxacum mongolieum Hand-Mass on Proliferation of Breast Cancer Cells and Nitric Oxide Production
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So Myung-Suk
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Abstract
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The effect of water extract from Taraxacum mongolieum Hand-Mass (TMW) on proliferation of human breast cancer cells, nitric oxide production and nitric oxide synthase expression was tested. TMW inhibited the growth of both estrogen-dependent MCF-7 and estrogen-independent MDA-MB-435 human breast cancer cells. Lipopolysaccharide-induced nitric oxide (NO) production was reduced by TMW in a concentration-dependent manner. Expression of inducible nitric oxide synthase (iNOS) was also suppressed with the treatment of TMW in Raw 264.7 cells. Therefore, Taraxacum mongolieum Hand-Mass is worth further investigation with respect to breast cancer therapy.
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KEYWORD
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Taraxacum mongolicum Hand-Mazz, nitric oxide, nitric oxide synthase, breast cancer
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